The default hot key for run (submit program) is the F8 key.
If you're using Base SAS (not EG), then you can type 'keys' into the box in the upper left hand corner, or by default hit F9, and bring up a window where you can set most of your hotkeys. You can also customize the toolbar buttons at the top of the window by right clicking on the toolbar and selecting 'customize'.
See http://www2.sas.com/proceedings/sugi28/240-28.pdf for more options.